Cushing’s disease in the dog
Cushing’s disease in the dog is a condition in which the adrenal glands produce too much hormone. It is a very common disease in dogs, especially small dog breeds. In the case of Cushing’s disease, too much cortisol is produced in the adrenal glands of the dog.
The adrenal glands make cortisol, among other things. This production is regulated via the pituitary gland. The pituitary gland converts the adrenal stimulating hormone to either ACTH. If a lot of this hormone is produced, the adrenal gland will produce a lot of cortisol and vice versa. This is shown schematically below.
In the case of Cushing’s disease too much cortisol is produced. This can be because:
– A small tumor grows from the pituitary gland. This makes too much ACTH, so the adrenals also produce too much ACTH. Approximately 85% of the dogs have this form.
– A benign tumor from the adrenal glands. This is much less common in the dog.
– A malignant tumor from the adrenal glands.
– What are the symptoms of Cushing’s disease in the dog?
– Drink a lot and urinate.
-Bald spots. Often this is symmetric and starts at the flanks. Dogs can eventually become completely bald.
-A fat belly.
-By the hind legs lower.
How can we treat Cushing to the dog?
When a tumor starts from the pituitary gland:
The tumor by removing a brain operation.
Tumor the tumor.
Suppress the adrenal glands with medication. Nowadays we usually use Trilostane (or Vetoryl).
In case of an adrenal tumor
By surgically removing the tumor
Suppress the adrenal glands with medication. Nowadays we usually use Trilostane (or Vetoryl). This is only possible with benign tumors.
How do you diagnose the disease of Cushing in the dog?
The diagnosis is difficult to establish. This is because there is no test that is 100% reliable. The urine test is most frequently performed in the Netherlands. Here, 3x urine is collected. On the second day we give 3 times dexamethasone (a type of cortisol) in high doses. The next day we catch urine again. The cortisol content is measured in the three urine tubes. At Cushing it is usually greatly increased. In addition, we often see high liver values ??in the blood, such as ALKP and ALT.
What is the prognosis of Cushing’s disease in the dog?
This is good with medication. However, the dogs have to be checked regularly to assess whether the dose of Vetoryl is sufficient.